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Ideal for those days when you’re feeling a little slow or unfocused but still want to get things done: it enhances mental clarity, decreases fatigue, while simultaneously boosting your mood and motivation.  


What is Sulbutiamine?

Sulbutiamine is a synthetic derivative of Vitamin B1 (thiamine). Or, more specifically, it is two vitamin B1 molecules joined together. Commonly described as an upgraded version of vitamin B1, Sulbutiamine has a much higher bioavailability than standard thiamine and can pass through your blood-brain barrier – thereby supplying your brain with the precious B1 vitamin.


Benefits of Sulbutiamine


Decreases fatigue

Is caffeine no longer doing the trick for you? If you suffer from chronic fatigue, try reaching out for Sulbutiamine instead of the 5th cup of coffee. According to several extensive studies, Sulbutiamine can significantly increase energy in people who are feeling fatigued. Ideal for those days when you're utterly exhausted but still have a full day of school, or work, to get through.


Boosts motivation and mood

There’s no way you’re going to conquer the world if you struggle to even get out of bed. Thankfully, research shows that through increasing dopamine and glutamate levels in your prefrontal cortex, Sulbutiamine can help boost motivation and give you the drive you need to power through the day. Sulbutiamine's effect on glutamate and dopamine has been linked to an enhanced mood as well.


Enhances mental clarity

Sharpen your mind with Sulbutiamine. Through boosting choline activity in the brain, Sulbutiamine supplementation can help better regulate levels of acetylcholine, a neurotransmitter that plays a critical role in memory formation. You can, therefore, look forward to better memory formation, short-term memory, and long-term memory.


Dosage guidelines

  • Dosage per day: 400 – 1000 mg per day
  • Effect onset: 30 – 60 minutes


Effect duration


Extended usage:

Tolerance can be an issue with Sulbutiamine. You may, therefore, find it beneficial to cycle on and off the supplement. A popular way of cycling Sulbutiamine is 3 days on, 1 day off – but you’re free to experiment until you find a cycle that best works for you.


Usage notes:

  • As Sulbutiamine is fat-soluble, be sure to take it with a fat source – this ensures that your body absorbs it.
  • Sulbutiamine is thought to have mild stimulant effects, so you might not want to take it too late into the night to prevent sleep interference.


Sulbutiamine side effects

While Sulbutiamine is well-tolerated at regular doses, some of the mild side effects reported include:

  • Bladder infections
  • Bronchitis
  • Arthritic pain
  • Back pain
  • Asthma
  • Abdominal pain
  • Insomnia
  • Constipation
  • Gastroenteritis
  • Diffuse pain
  • Sinusitis
  • Headache
  • Kidney pain

Also, individuals belonging to the following groups should consult with a doctor before supplementing with Sulbutiamine:

  • Pregnant or lactating women.
  • People with certain psychiatric disorders, such as bipolar disorders.
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